What is the drug alteplase used for?

Alteplase injection is used to dissolve blood clots that have formed in the blood vessels. It is used immediately after symptoms of a heart attack occur to improve patient survival. It is also used after symptoms of a stroke and to treat blood clots in the lungs (pulmonary embolism).

What is the generic name of alteplase?

Alteplase is marketed as Actilyse, Activase, and Cathflo or Cathflo Activase.

Is alteplase a type of tPA?

Known by the generic name alteplase and marketed as Activase® (Genentech), tPA is given to patients through an IV in the arm, and it works by dissolving blood clots that block blood flow to the brain.

Is alteplase an antithrombotic?

Alteplase and Aspirin

This is the only antithrombotic agent that has proven to be effective at preventing early ischemic recurrence and at improving the prognosis for cerebral infarction.

Is alteplase a heparin?

Alteplase is significantly more effective than heparin in preventing clot formation in central haemodialysis lines. This reduces morbidity and improves preservation of central venous access.

What drug classification is retavase?

Retavase belongs to a class of drugs called Thrombolytics.

Is alteplase a blood thinner?

What is alteplase? Alteplase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a “clot-busting” drug. It helps your body produce a substance that dissolves unwanted blood clots.

What is the mechanism of action of tPA?

Mechanism of Action

tPA attaches to the fibrin on the clot surface. It activates the fibrin-bound plasminogen. Plasmin is subsequently cleaved from the plasminogen affiliated with the fibrin. The plasmin breaks up the molecules of fibrin, and the clot dissolves.

What is the difference between alteplase and streptokinase?

Alteplase is a pharmacologic tPA and functions in the same way. Streptokinase: Streptococci produce this substance. When given as a drug, streptokinase works with the body’s own supply of plasminogen. Plasminogen, in the presence of streptokinase, will become plasmin at a fast rate.

What is the generic name for Tricor?

Tricor (fenofibrate) is an antilipemic agent and fibric acid prescribed for reducing “bad” cholesterol and fats (for example, LDL and triglycerides) and for raising “good” cholesterol (HDL) in the blood.

Which of the drug is fibrinolytic?

Four fibrinolytic drugs are currently marketed: streptokinase, anisoylated plasminogen-streptokinase activator complex, urokinase, and recombinant human tissue-type plasminogen activator. All 4 of these drugs activate the fibrinolytic system by converting plasminogen to the active enzyme, plasmin.

What is the difference between alteplase and streptokinase?

Alteplase is a pharmacologic tPA and functions in the same way. Streptokinase: Streptococci produce this substance. When given as a drug, streptokinase works with the body’s own supply of plasminogen. Plasminogen, in the presence of streptokinase, will become plasmin at a fast rate.

Is Cathflo the same as tPA?

What brand names are available for alteplase? TPA, Activase, and Cathflo Activase are brand names available for alteplase.

What is the mechanism of action of alteplase?

Mechanism of Action

Alteplase converts plasminogen to the proteolytic enzyme plasmin, which lyses fibrin as well as fibrinogen. Intravenous alteplase is cleared primarily by the liver with an initial half-life of fewer than 5 minutes and a terminal half-life of 72 minutes.

What is the difference between thrombolytics and Fibrinolytics?

Thrombolysis refers to the dissolution of the thrombus due to various agents while fibrinolysis refers specifically to the agents causing fibrin breakdown in the clot.

What are the anticoagulant drugs?

Anticoagulants work by interrupting the process involved in the formation of blood clots. They’re sometimes called “blood-thinning” medicines, although they don’t actually make the blood thinner.
…
These include:
  • rivaroxaban (Xarelto)
  • dabigatran (Pradaxa)
  • apixaban (Eliquis)
  • edoxaban (Lixiana)

What are the contraindications for alteplase?

Alteplase is contraindicated in patients with severe uncontrolled hypertension. In adult patients with systolic blood pressure of 175 mmHg or more and/or diastolic blood pressure of 110 mmHg or more, the risks of bleeding with alteplase therapy are increased and should be weighed against the potential benefits.

Why is alteplase given for stroke?

Introduction. Intravenous thrombolysis with recombinant tissue-type plasminogen activator (r-tPA), alteplase, improves survival free of dependency for ≤18 months after stroke, despite the risk of early symptomatic intracranial hemorrhage (sICH).

What is the antidote for tPA?

by Drugs.com

Aprotinin: an antidote for recombinant tissue-type plasminogen activator (rt-PA) active in vivo.

When should alteplase be given?

“There is a treatment for your stroke called alteplase that must be given within 4.5 hours after the stroke started. It is a ‘clot-buster’ drug.