What is morphological classification of anemia?

Anemia can be classified as microcytic, normocytic or macrocytic, depending on MCV. As stated above, it can be hypo-regenerative or regenerative, which depends on the number of reticulocytes.

Why is the morphological classification of anemia important?

Categorizing an anemia based on morphology is useful in determining the underlying condition. For example, microcytic, hypochromic cells are seen in iron-deficiency anemia, and macrocytic, normochromic cells are characteristic of a deficiency of B12 or folic acid.

How are different types of anemia classified?

Anemia can also be classified based on the size of the red blood cells and amount of hemoglobin in each cell. If the cells are small, it is called microcytic anemia; if they are large, it is called macrocytic anemia; and if they are normal sized, it is called normocytic anemia.

How anemia is classified based on morphology and hemoglobin concentration?

Anemia can be classified according to a deficient number of circulating red blood cells or a deficient hemoglobin concentration, or both. A classification of anemia on the basis rbc morphology, as seen in the peripheral blood smear and supported by the quantitative measurements of cell size (MCV) and-Hb.

How do microcytic and macrocytic anemia differ?

In microcytic anemia, red blood cells (RBCs) are smaller than normal. In macrocytic anemia, RBCs are larger than normal. Making this distinction in the size of RBCs will help doctors figure out the cause of a person’s anemia.

What are the 6 types of anemia?

They include:
  • Iron deficiency anemia. This most common type of anemia is caused by a shortage of iron in your body. …
  • Vitamin deficiency anemia. …
  • Anemia of inflammation. …
  • Aplastic anemia. …
  • Anemias associated with bone marrow disease. …
  • Hemolytic anemias. …
  • Sickle cell anemia.

Is haemolytic Anaemia normocytic or macrocytic?

Hemolytic anemia is classified as normocytic anemia with an MCV of 80 to 100 fL. It is a form of low hemoglobin due to the destruction of red blood cells, increased hemoglobin catabolism, decreased levels of hemoglobin, and an increase in efforts of bone marrow to regenerate products.

Is iron deficiency anemia normocytic or microcytic?

Less than 25% of normocytic normochromic anemia cases progress to microcytic hypochromic anemia, in which case the mean corpuscular volume is rarely less than 70. [9] This measure stands in contrast to iron deficiency anemia, which is mostly microcytic.

Who anemia classification based on hemoglobin?

According to the World Health Organization (WHO), anemia is defined as hemoglobin (Hb) levels <12.0 g/dL in women and <13.0 g/dL in men. However, normal Hb distribution varies not only with sex but also with ethnicity and physiological status.

How is anemia classified clinically on the basis of blood indices?

Anemias are classified, according to the size of the red cell, as being normocytic (normal MCV), macrocytic (increased MCV), or microcytic (decreased MCV). Microcytic anemias were also often described as being hypochromic based on peripheral smear examination and MCHC when this value was determined manually.

What is pathophysiological classification based on?

The pathophysiologic classification system of anemia is divided into two broad categories. These categories are based on the underlying cause of the decrease in RBCs in the circulation. The categories are: Anemia caused by decreased production of RBCs.

What is the objective of managing anemia?

The goal of treatment is to increase the amount of oxygen that your blood can carry. This is done by raising the red blood cell count and/or hemoglobin level. (Hemoglobin is the iron-rich protein in red blood cells that carries oxygen to the body.) Another goal is to treat the underlying cause of the anemia.

WHO classification anemia in adults?

According to the World Health Organization (WHO), anemia is defined as hemoglobin (Hb) levels <12.0 g/dL in women and <13.0 g/dL in men. However, normal Hb distribution varies not only with sex but also with ethnicity and physiological status.

Is Sickle cell anemia microcytic or macrocytic?

These data indicate that Hb SS disease is associated with “relative microcytosis,” presumably a consequence of reduced hemoglobin production.

What are the types of Macrocytic anemia?

The two most common forms of macrocytic anemia are megaloblastic macrocytic anemia and non-megaloblastic macrocytic anemia. Megaloblastic macrocytic anemia: This form of macrocytic anemia happens when you don’t get enough vitamin B12 and/or vitamin B6 (folate).

What is the pathophysiology of Anaemia?

Anemia generally results from blood loss, decreased red blood cell (RBC) production, poor RBC maturation, or increased RBC destruction.

Is thalassemia a microcytic anemia?

Thalassemias are a common cause of hypochromic microcytic anemia which arises from the reduced or absent synthesis of the globin chain of hemoglobin. Thalassemias are a quantitative defect of hemoglobin synthesis.

Is haemolytic Anaemia normocytic or macrocytic?

Hemolytic anemia is classified as normocytic anemia with an MCV of 80 to 100 fL. It is a form of low hemoglobin due to the destruction of red blood cells, increased hemoglobin catabolism, decreased levels of hemoglobin, and an increase in efforts of bone marrow to regenerate products.

What is the difference between normocytic and microcytic anemia?

Anaemia is classified by the average size of RBCs: microcytic (smaller RBC size than normal), normocytic (normal RBC size) and macrocytic (larger RBC size than normal).

What are the 4 types of thalassemia?

Alpha thalassemia occurs when some or all of the 4 genes that make hemoglobin (the alpha-globin genes) are missing or damaged.
…
There are 4 types of alpha thalassemia:
  • Alpha thalassemia silent carrier. …
  • Alpha thalassemia carrier. …
  • Hemoglobin H disease. …
  • Alpha thalassemia major.

What is Fanconi Anaemia?

Fanconi anemia is a rare disease passed down through families (inherited) that mainly affects the bone marrow. It results in decreased production of all types of blood cells. This is the most common inherited form of aplastic anemia. Fanconi anemia is different from Fanconi syndrome, a rare kidney disorder.