Classification of antimalarial ppt
What are the classification of antimalarial?
The 4 major drug classes currently used to treat malaria include quinoline-related compounds, antifolates, artemisinin derivatives, and antimicrobials.
What are antimalarials Slideshare?
Pyrimethamine • Diaminopyrimidine more potent than proguanil & effective against erythrocytic forms of all species. Tasteless so suitable for children Adverse events: megaloblastic anemia, thrombocytopenia, agranulocytosis.
What are antimalarial drugs PDF?
The antimalarials in common use come from the following classes of compounds: the quinolines (chloroquine, quinine, mefloquine, amodiaquine, primaquine), the antifolates (pyrimethamine, proguanil and sulfadoxine), the artemisinin derivatives (artemisinin, artesunate, artemether, arteether) and hydroxynaphthaquinones ( …
What is the classification of chloroquine?
Chloroquine phosphate is in a class of drugs called antimalarials and amebicides. It works by killing the organisms that cause malaria and amebiasis.
What are examples of antimalarial drugs?
When several different drugs are recommended for an area, the following table might help in the decision process.
- Atovaquone/Proguanil (Malarone)
- Chloroquine.
- Doxycycline.
- Mefloquine.
- Primaquine.
- Tafenoquine (ArakodaTM)
What are antimalarial drugs used for?
Antimalarial drugs are used for the treatment and prevention of malaria infection. Most antimalarial drugs target the erythrocytic stage of malaria infection, which is the phase of infection that causes symptomatic illness (figure 1).
What is another name for chloroquine?
What is chloroquine? Chloroquine (also known as chloroquine phosphate) is an antimalarial medicine. It is available in the United States by prescription only. It is sold under the brand name Aralen, and it is also sold as a generic medicine.
What is the mechanism of action of antimalarial?
The quinoline-containing antimalarial drugs, chloroquine, quinine and mefloquine, are a vital part of our chemotherapeutic armoury against malaria. These drugs are thought to act by interfering with the digestion of haemoglobin in the blood stages of the malaria life cycle.
What is the chemical name of chloroquine?
Chloroquine
| Clinical data | |
|---|---|
| IUPAC name (RS)-N’-(7-chloroquinolin-4-yl)-N,N-diethyl-pentane-1,4-diamine | |
| CAS Number | 54-05-7 |
| PubChem CID | 2719 |
| IUPHAR/BPS | 5535 |
What is malaria disease?
Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. People who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. Four kinds of malaria parasites infect humans: Plasmodium falciparum, P.
What is mechanism of action of antimalarial agent?
The quinoline-containing antimalarial drugs, chloroquine, quinine and mefloquine, are a vital part of our chemotherapeutic armoury against malaria. These drugs are thought to act by interfering with the digestion of haemoglobin in the blood stages of the malaria life cycle.
What is Malarias life cycle?
The malaria parasite life cycle involves two hosts. During a blood meal, a malaria-infected female Anopheles mosquito inoculates sporozoites into the human host . Sporozoites infect liver cells and mature into schizonts , which rupture and release merozoites .
What causes malaria fever?
Malaria is an acute febrile illness caused by Plasmodium parasites, which are spread to people through the bites of infected female Anopheles mosquitoes. There are 5 parasite species that cause malaria in humans, and 2 of these species – P. falciparum and P. vivax – pose the greatest threat.
What is the first drug to treat malaria?
Quinine and its derivatives
The first pharmaceutical used to treat malaria, quinine, was derived from the tree bark of Cinchona calisaya [5]. Quinine synthesis was first attempted in 1856 by William Henry Perkins, but synthesis was not successful until 1944.
What are antimalarial drugs structure?
8-Aminoquinoline Analogs
8-aminoquinoline is another class of quinoline-based antimalarial drug that contains three members, primaquine, tafenoquine and pamaquine, which are used in the treatment of malaria. They may be used to eradicate malarial hypnozoites from the liver and have been used for malarial prophylaxis.