What is classification of brimonidine?

Brimonidine is in a class of drugs called alpha adrenergic agonists. Brimonidine works by decreasing the amount of fluid in the eyes.

What is brimonidine mechanism of action?

Brimonidine has a dual mechanism of IOP lowering: it both reduces aqueous humor production and stimulates aqueous humor outflow through the uveoscleral pathway (Toris et al 1995).

What is brimonidine tartrate?

The tartrate salt form of brimonidine, an imidazole derivative and a selective alpha-2 adrenergic receptor agonist. Upon ocular administration, brimonidine tartrate acts on the blood vessels causing them to constrict which leads to a decrease in the production of aqueous humor.

What is another name for brimonidine tartrate?

Alphagan P (brimonidine tartrate) Ophthalmic Solution is an antiglaucoma medication used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye). Some strengths of Alphagan P are available in generic form.

Is brimonidine tartrate a beta blocker?

Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) is a combination of an alpha agonist and a beta-blocker that work to reduce pressure inside the eye used to treat glaucoma or ocular hypertension (high pressure inside the eye).

What drug class is used for glaucoma?

Medication classes historically used in the management of glaucoma include beta blockers, miotics, sympathomimetics and carbonic anhydrase inhibitors. Because topically applied medications are more site specific, they are preferred in the treatment of glaucoma.

Is brimonidine tartrate a vasoconstrictor?

Brimonidine tartrate 0.5% gel is approved as a vasoconstrictor for the treatment of nontransient facial erythema secondary to rosacea. As brimonidine affects vasoconstriction primarily via the α2-adrenergic receptor, it may have decreased potential for rebound redness or tachphylaxis.

Is brimonidine the same as Latanoprost?

Conclusions: At peak effect, brimonidine twice daily was as effective as latanoprost once daily in lowering IOP. In treatment-naive patients, latanoprost was associated with a significantly higher rate of nonresponse after 3 months of treatment compared with brimonidine.

How does brimonidine cause vasoconstriction?

As brimonidine affects vasoconstriction primarily via the α2-adrenergic receptor, it may have decreased potential for rebound redness or tachphylaxis. Brimonidine’s effect on conjunctival blood vessels is dose dependent; at the high doses used for intraocular pressure lowering, it has been associated with hyperemia.

How does brimonidine reduce intraocular pressure?

Brimonidine tartrate 0.2% is an effective alpha2 adrenergic agonist, that lowers intraocular pressure (IOP) by decreasing aqueous production and increasing uveoscleral outflow. Brimonidine has been shown to effectively lower IOP in glaucomatous, ocular hypertensive and normotensive eyes.

What does brimonidine do for skin?

Brimonidine topical gel is used in adults to treat facial redness that does not go away and caused by rosacea (a skin disease). This medicine is available only with your doctor’s prescription.

How does brimonidine work for rosacea?

This medication is used to treat a certain skin disorder called rosacea. It works by narrowing blood vessels to reduce redness. Brimonidine belongs to a class of drugs known as alpha agonists.

What medications increase eye pressure?

Steroids. Corticosteroids, or steroids, can raise eye pressure, especially in those persons who have open-angle glaucoma, first-degree relatives of those with open-angle glaucoma, elderly and young (<6 years) persons, those with type 1 diabetes and those with high myopia (short-sightedness).

Does brimonidine lower blood pressure?

Brimonidine was associated with a reduction in average mean blood pressure and pulse rate (p = 0.026, p = 0.021, respectively).