What are the major types of acute leukemias?

The major types of leukemia are:
  • Acute lymphocytic leukemia (ALL). This is the most common type of leukemia in young children. …
  • Acute myelogenous leukemia (AML). AML is a common type of leukemia. …
  • Chronic lymphocytic leukemia (CLL). …
  • Chronic myelogenous leukemia (CML). …
  • Other types.

How do you classify acute myeloid leukemia?

In the revised 4th edition of the WHO classification published in 2017 [3], AML is classified into 6 categories: AML with recurrent genetic abnormalities; AML with myelodysplasia-related changes (MRC); therapy-related myeloid neoplasms (t-MN); AML, not otherwise specified (NOS); myeloid sarcoma; and myeloid …

WHO classification acute lymphoblastic leukemia?

WHO classification of acute lymphoblastic leukemia. The WHO classifies ALL as B-lymphoblastic leukemia/lymphoma or T-lymphoblastic leukemia/lymphoma. The 2016 revision includes several provisional entities.

What are the different classifications of leukemia?

There are 4 main types of leukemia, based on whether they are acute or chronic, and myeloid or lymphocytic: Acute myeloid (or myelogenous) leukemia (AML) Chronic myeloid (or myelogenous) leukemia (CML) Acute lymphocytic (or lymphoblastic) leukemia (ALL)

WHO classification AML pathology?

Acute myeloid leukemia not otherwise categorized:

AML minimally differentiated (M0) AML without maturation (M1) AML with maturation (M2) Acute myelomonocytic leukemia (M4)

What are the two different types of acute lymphocytic leukemia?

Types of leukaemia
  • acute myeloid leukaemia (AML) affects myeloid cells.
  • acute lymphoblastic leukaemia (ALL) affects lymphoid cells.

What are the two types of acute lymphocytic leukemia?

Acute lymphocytic leukemia (ALL) can be characterized into different sub-types:
  • Philadelphia chromosome-positive ALL.
  • Philadelphia chromosome-negative ALL.
  • B cell ALL.
  • T cell ALL.

What are the two main types of leukemia?

Leukemia is classified in two ways. First, the disease can be either chronic (slow-growing) or acute (more aggressive). Second, leukemia is classified based on the types of leukemia cells present. This is determined by where the disease started.

How are leukemias classified in general and more specifically how are Amls classified?

Leukemias are classified according to their acute and chronic progress as well as according to their lymphoid or myeloid cell origins. Acute myeloid leukemia is further classified into subtypes. Most cancers and solid tumors are classified according to cell type, aggressiveness and propensity to spread to other organs.

WHO classification vs Fab?

Two staging systems are commonly used for acute myeloid leukemia (AML). The French-American-British (FAB) classification system is based on morphology to define specific immunotypes. The World Health Organization (WHO) classification reviews chromosome translocations and evidence of dysplasia.

What are the various stages of myeloid series of cells?

In CML, the bone marrow generates too many abnormal white cells, called myeloid series (CML cells). The developmental stages of the CML cells, from immature to mature include: Myeloblasts, Promyelocytes, Myelocytes, Metamyelocytes, Bands and Neutrophils (Zittoun et al., 1994[38]).

What is the prognosis of AML?

Prognosis and Prognostic Factors

Approximately 60% to 70% of adults with AML can be expected to attain CR status after appropriate induction therapy. More than 25% of adults with AML (about 45% of those who attain CR) can be expected to survive 3 or more years and may be cured.

WHO AML classification vs Fab?

The most important difference between the WHO and FAB classifications is the lowering of the blast threshold for the diagnosis of AML from 30% to 20% blasts in the blood or bone marrow. As a result, the FAB category RAEBT is eliminated from the WHO proposal (Table 2).

What is FAB classification of acute lymphoblastic leukemia?

The French-American-British (FAB) classification of acute lymphoblastic leukemia introduced in 1976 was based on morphology alone and recognized three types of blast cells in ALL, namely: small homogeneous blasts with round nuclei and scanty cytoplasm (L1), larger blasts with irregular nuclei, prominent nucleoli and …

What is non m3 AML?

Acute myeloid leukemia (AML) is a heterogeneous condition characterized by clonal proliferation of myeloid precursors and accumulation of leukemic blasts in the bone marrow (BM), ultimately resulting in failure of the BM. It accounts for approximately 80% of cases of acute leukemia in adults.

WHO classification Who?

The WHO Family of International Classifications and Terminologies includes: the International Statistical Classification of Diseases and Related Health Problems (ICD), the International Classification of Functioning, Disability and Health (ICF), and the International Classification of Health Interventions (ICHI).