Do antibiotics affect collagen?

It’s not clear how the drugs contribute to tendon issues, but they believe that the antibiotics may affect blood flow to collagen in the muscles, which makes up tendons. There were enough cases that in 2008, the Food and Drug Administration (FDA) added a black box warning to the drugs about the risk of tendonitis.

What class of antibiotics may cause tendon rupture?

The new warnings apply to fluoroquinolones, a class of antibiotics that includes the popular drug Cipro. The FDA has told companies that the drugs must now carry “black box” warnings alerting doctors and patients that the drugs can increase risk of tendinitis and tendon rupture in some patients.

What are the 4 classes of antibiotics?

Antibiotic class defines a set of related antibiotics. State-level rates of penicillins, macrolides, cephalosporins, and fluoroquinolones are displayed. Also displayed are all antibiotic classes, which include these four classes plus additional classes not available for release at the state level.

Which class of antibiotics may impede cartilage formation?

From these studies it has been inferred that fluoroquinolones could adversely affect the human skeletal system including the growth plate cartilage.

Which fluoroquinolone has highest risk of tendon rupture?

Ofloxacin had the highest risk of tendon injury in three of the studies.

Do all fluoroquinolones cause tendon rupture?

Conclusions In our study, fluoroquinolones as a class were not associated with the increased risk of tendon ruptures. Neither ciprofloxacin nor moxifloxacin exhibited any risk for tendon ruptures.

Why does fluoroquinolones cause cartilage damage?

Fluoroquinolones decrease proliferation of chondrocytes and damage cartilage by decreasing magnesium concentrations by forming quinolone-magnesium complexes.

Can amoxicillin cause tendon damage?

It’s also the most affected by fluoroquinolones. The antibiotics quadruple the risk of Achilles tendon rupture. The higher your dosage and the longer you take the medication, the greater the danger.

Why does levofloxacin cause tendon rupture?

It is believed that the different chemical structure of newer FQ (levofloxacin, ofloxacin and pefloxacin) makes them more toxic on cartilages and tendons than older FQ (norfloxacin, ciprofloxacin and enoxacin).

How do fluoroquinolones affect tendons?

The most common presenting symptom of fluoroquinolone-associated tendinopathy is pain. This pain is usually of a sudden onset and may be accompanied by acute signs of inflammation and swelling. Achilles tendon rupture may be preceded by pain,25,26 but half of tendon ruptures have been reported to occur without warning.

Does levofloxacin cause tendon rupture?

Taking levofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward.

What medications can cause tendon problems?

Medications (rare occurrence) that can cause tendons to tear. These medications can include: Fluoroquinolone antibiotics (such as ciprofloxacin [Cipro®] and norfloxacin [Noroxin®]). Statins (drugs that lower cholesterol).
…
These diseases can include:
  • Rheumatoid arthritis.
  • Gout/pseudogout.
  • Blood or kidney diseases.

How does ciprofloxacin affect tendons?

Taking ciprofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward.

Can amoxicillin cause tendon damage?

It’s also the most affected by fluoroquinolones. The antibiotics quadruple the risk of Achilles tendon rupture. The higher your dosage and the longer you take the medication, the greater the danger.

What is the major side effect of clindamycin?

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you or your child are using this medicine.

Can ciprofloxacin cause permanent damage?

Fluoroquinolone medicines (which contain ciprofloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, ofloxacin, pefloxacin, prulifloxacin and rufloxacin) can cause long-lasting, disabling and potentially permanent side effects involving tendons, muscles, joints and the nervous system.

Can cephalexin cause tendon damage?

Therefore, even though the drug does not have a direct detrimental effect on the tendon, it results in an increased risk of tendon rupture following acute stress [1-2,9].