What are the classes of antiplatelet drugs?

Classes of antiplatelet drugs include:
  • Irreversible cyclooxygenase inhibitors. Aspirin. …
  • Adenosine diphosphate (ADP) receptor inhibitors. …
  • Phosphodiesterase inhibitors. …
  • Protease-activated receptor-1 (PAR-1) antagonists. …
  • Glycoprotein IIB/IIIA inhibitors (intravenous use only) …
  • Adenosine reuptake inhibitors. …
  • Thromboxane inhibitors.

What is the most common antiplatelet drug?

The most common antiplatelet drug used in preventing further heart attacks is aspirin. Other drugs include clopidogrel, prasugrel and ticagrelor.

What is the mechanism of action of antiplatelets?

Mechanism of action: The thienopyridine derivatives (clopidogrel and ticlopidine) are metabolised in the liver to active compounds which covalently bind to the adenosine phosphate (ADP) receptor on platelets and dramatically reduce platelet activation (see Box 1).

What is the best antiplatelet medication?

Clopidogrel (75 mg daily) is the preferred antiplatelet. If intolerant of clopidogrel, aspirin in combination with modified-release dipyridamole (200 mg twice a day).

What is difference between antiplatelet and anticoagulant?

There are different types of blood thinners: Anticoagulants, such as heparin or warfarin (also called Coumadin), slow down your body’s process of making clots. Antiplatelets, such as aspirin and clopidogrel, prevent blood cells called platelets from clumping together to form a clot.

When are antiplatelet drugs used?

Antiplatelet drugs are sometimes used to prevent blood clots, heart attacks and strokes, but are primarily used to prevent the recurrence of blood clots after a heart attack or stroke. They can also help relieve symptoms such as chest pain, poor circulation and shortness of breath.

Which is better Plavix or aspirin?

Clopidogrel is another guideline‐recommended antiplatelet agent21 and has been shown to be superior to aspirin in preventing composite vascular events and reducing hemorrhagic complications in a randomized controlled trial, CAPRIE (Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events).

What is a good substitute for Plavix?

  • Aggrenox.
  • Pravastatin.
  • Brilinta.
  • Ticagrelor.
  • Aspirin / dipyridamole.
  • Bayer Aspirin.

Who should not take clopidogrel?

Clopidogrel must not be given to anyone under 18 years old, unless under specialist advice. It’s also not recommended if you’re pregnant or breastfeeding. Your doctor or dentist may advise you to stop taking clopidogrel for a short time before a procedure or dental treatment.

What is the best painkiller to take with Plavix?

Usually, your doctor or pharmacist will recommend that you take acetaminophen (Tylenol) if you’re using Plavix. This is because acetaminophen is an over-the-counter (OTC) pain medication that’s least likely to cause bleeding.

Is there a safer drug than Plavix?

According to the American Heart Association (AHA) and American College of Cardiology (ACC), Brilinta is a preferred treatment for people with ACS. Brilinta works faster and has a reversible mode of action. It also has better platelet inhibition and patient outcomes compared to Plavix.

Is there a better blood thinner than Plavix?

Brilinta (ticagrelor) appears to be slightly more effective than Plavix (clopidogrel) in reducing the percentage of CV death, MI or stroke in the first year of treatment. Brilinta patients had more breathing difficulties as a side effect compared to Plavix patients.

Can clopidogrel be stopped suddenly?

Do not stop taking clopidogrel without talking to your doctor. If you stop taking clopidogrel, your blood will start clotting at the same rate as before you started taking it, usually within 5 days of stopping the medicine. This means you may be at increased risk of serious problems like heart attacks or strokes.

Can Plavix cause memory loss?

What should I go over with my doctor? Some patients have no side effects, have had very good results with Plavix and even credit it with saving their lives. Others have had many different side effects, bruising, uncontrollable bleeding, memory loss, fatigue, swelling of hands and feet and many more.

When can I stop Plavix after a stent?

Stopping dual antiplatelet therapy (DAPT) (eg, clopidogrel plus aspirin) after 3 months is reasonable in patients with stable ischemic heart disease who have a second-generation drug-eluting stent and a high bleeding risk, with stable ischemic disease defined as at least 1 year free of acute coronary syndromes.

Which is stronger warfarin or Plavix?

The use of warfarin is considered “full anticoagulation” and is felt to be more effective (a higher level) than other oral blood thinners. Plavix is a drug known as an anti-platelet drug.

Does clopidogrel affect sleep?

The organic nitrates (isosorbide) and the antiplatelet agents (acetylsalicylic acid, clopidogrel) are among the most prescribed drugs in cardiology and are not cited as causing insomnia or sleepiness.

Why does Plavix make you tired?

Tiredness. Plavix may cause symptoms of tiredness or weakness for multiple reasons. Plavix increases the risk of bleeding, and individuals may feel more tired than usual if blood loss occurs. High levels of blood loss can also lead to low blood pressure, which also causes weakness, dizziness, and fatigue.