What is the classification of Reyataz?

Reyataz belongs to a class of drugs called HIV, Protease Inhibitors; Antiretroviral Agents.

What is the classification of ritonavir?

Ritonavir belongs to a class of drugs known as protease inhibitors. It increases (“boosts”) the levels of other protease inhibitors, which helps these medications work better.

What is another name for atazanavir?

Atazanavir (brand name: Reyataz) is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 3 months of age and older who weigh at least 11 lb (5 kg). Atazanavir is always used in combination with other HIV medicines.

What drug class is cobicistat in?

Cobicistat is in a class of medications called pharmacokinetic boosters. It works by increasing the amount of atazanavir or darunavir in the body so that they can have a greater effect.

What type of inhibitor is ritonavir?

HIV protease inhibitor
Ritonavir is a HIV protease inhibitor routinely prescribed to HIV patients that also potently inactivates cytochrome P4503A4 (CYP3A4), the major human drug-metabolizing enzyme.

Which drugs are protease inhibitors?

The protease inhibitors approved by the Food and Drug Administration (FDA) include:
  • atazanavir sulfate (Reyataz)
  • darunavir ethanolate (Prezista)
  • fosamprenavir calcium (Lexiva)
  • ritonavir (Norvir)
  • saquinavir mesylate (Invirase)
  • tipranavir (Aptivus)
  • indinavir sulfate (Crixivan)
  • nelfinavir mesylate (Viracept)

What are CYP3A drugs?

CYP3A inducers include the glucocorticoids, rifampin, carbamazepine, phenobarbital, and phenytoin. Among the many significant CYP3A inhibitors are grapefruit juice, erythromycin, ketoconazole, clarithromycin, and verapamil.

What is another name for PREZCOBIX?

Prezcobix (darunavir / cobicistat) is a combination medication used with other HIV antiretroviral medications (ARVs) for the treatment of HIV. It contains a protease inhibitor (a type of ARV) called darunavir and an HIV medication “booster” called cobicistat.

What type of drug is elvitegravir?

The combination of elvitegravir, cobicistat, emtricitabine, and tenofovir is in a class of medications called antivirals. Elvitegravir, emtricitabine, and tenofovir work by decreasing the amount of HIV in the blood.

What is the drug ritonavir used for?

Descriptions. Ritonavir is used together with other medicines for the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Ritonavir will not cure or prevent HIV infection or AIDS.

What is the role of ritonavir?

Ritonavir is a protease inhibitor used for the treatment of HIV/AIDS. It is seldom employed for its own antiviral activity but instead serves as a booster for other protease inhibitors. Although ritonavir was initially designed to inhibit HIV protease, studies have found that it also inhibits cytochrome P450-3A4.

Is ritonavir an antiviral?

Because ritonavir-boosted nirmatrelvir is the only highly effective oral antiviral for the treatment of COVID-19, drug-drug interactions that can be safely managed should not preclude the use of this medication.

Is ritonavir an inducer or inhibitor?

Data synthesis: Ritonavir is a well-known inhibitor of the metabolism of numerous medications that are substrates of the CYP3A and CYP2D6 pathways. It also exhibits a biphasic, time-dependent effect on P-glycoprotein of inhibition followed by induction.

Why is atazanavir combined with ritonavir?

Pharmacology. Although atazanavir can be administered alone to treatment-naive patients who cannot tolerate ritonavir, it is preferably co-administered with low-dose ritonavir to optimize its pharmacokinetic parameters and efficacy (Table 1) [5].

What drugs contain ritonavir?

  • Brand name: Norvir. Drug classes: antiviral boosters, protease inhibitors.
  • Brand names: Viekira Pak, Viekira XR. Drug class: antiviral combinations.
  • Brand name: AccessPak for HIV PEP Expanded with Kaletra. Drug class: antiviral combinations.
  • Brand name: Kaletra. …
  • Brand name: Paxlovid. …
  • Brand name: Technivie.

Is ritonavir a prodrug?

Water-soluble prodrugs of the human immunodeficiency virus protease inhibitors lopinavir and ritonavir.

Is atazanavir a protease inhibitor?

[22] HIV protease inhibitors are a key component of highly active antiretroviral combination therapy (HAART) for patients infected with HIV; mutations in HIV protease lead to their drug resistance. [23] Atazanavir was the first protease inhibitor that received approval for once-daily dosing.

How is atazanavir given?

Atazanavir comes as a capsule and as a powder to take by mouth. Atazanavir capsules are taken with food once a day and may be given with a pharmacokinetic booster (medication given to increase the levels of another drug in the body) such as ritonavir or cobicistat.