What class of drug is brinzolamide?

Brinzolamide is in a class of medications called carbonic anhydrase inhibitors. It decreases the pressure in the eye.

What is brimonidine mechanism of action?

Brimonidine has a dual mechanism of IOP lowering: it both reduces aqueous humor production and stimulates aqueous humor outflow through the uveoscleral pathway (Toris et al 1995).

What is brimonidine used for?

Brimonidine eye drops is used alone or together with other medicines to lower pressure inside the eye that is caused by open-angle glaucoma or ocular (eye) hypertension. This medicine is an alpha-adrenergic agonist. Brimonidine eye drops is also used to relieve redness of the eye caused by minor eye irritations.

What is another name for brimonidine?

Alphagan P is a brand name for the prescription-only version of brimonidine, and is available in 0.1%, 0.15%, and 0.2% strengths. Qoliana is another brand name for prescription strength brimonidine. Lumify is the brand name for the over-the-counter version of this medication and is available in a 0.025% strength.

What is the generic name for brimonidine?

Alphagan P (brimonidine tartrate) Ophthalmic Solution is an antiglaucoma medication used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye). Some strengths of Alphagan P are available in generic form.

What is the composition of brimonidine?

Brimonidine tartrate 0.2% w/v (2.0 mg/ml). Benzalkonium chloride 0.005% w/v.

What drug class is used for glaucoma?

Medication classes historically used in the management of glaucoma include beta blockers, miotics, sympathomimetics and carbonic anhydrase inhibitors. Because topically applied medications are more site specific, they are preferred in the treatment of glaucoma.

What drugs interact with brimonidine?

Some products that may interact with this drug include: beta-blockers (such as atenolol, metoprolol, timolol eye drops), digoxin, high blood pressure medications (such as clonidine, terazosin), tricyclic antidepressants (such as amitriptyline).

What is the difference between brimonidine and brinzolamide?

These two medications work together to decrease the amount of fluid within the eye. Brinzolamide belongs to a class of drugs known as carbonic anhydrase inhibitors. Brimonidine belongs to a class of drugs known as alpha agonists.

Is brimonidine a vasoconstrictor?

Brimonidine tartrate 0.5% gel is approved as a vasoconstrictor for the treatment of nontransient facial erythema secondary to rosacea. As brimonidine affects vasoconstriction primarily via the α2-adrenergic receptor, it may have decreased potential for rebound redness or tachphylaxis.

What does brimonidine do for skin?

This medication is used to treat a certain skin disorder called rosacea. It works by narrowing blood vessels to reduce redness. Brimonidine belongs to a class of drugs known as alpha agonists.

Why does brimonidine cause hypotension?

Brimonidine is an α2-agonist that exerts its ocular hypotensive effect primarily by decreasing aqueous humor flow, 25 and it has been shown to have a daytime effect similar to that of timolol.

Why does brimonidine cause Miosis?

Brimonidine binds to those receptors and, by doing so, inhibits further release of neurotransmitter into the synaptic cleft. Thus, when brimonidine is introduced to the eye, the dilator muscle will experience reduced activity, causing less pupil dilation and resulting in a more miotic pupil (Figure 2).

Can brimonidine cause vision loss?

Commonly reported side effects of brimonidine ophthalmic include: blurred vision, burning sensation of eyes, drowsiness, eye pruritus, follicular conjunctivitis, headache, local ocular hypersensitivity reaction, ocular hyperemia, stinging of eyes, foreign body sensation, and xerostomia.

Is brimonidine safe for skin?

Brimonidine topical gel 0.33% is a safe, effective, and patient-accepted treatment for facial erythema of rosacea.

Does brimonidine cause fatigue?

The most common adverse reactions to brimonidine are dry mouth, fatigue/drowsiness, and blurring of vision, which occurred significantly more often with brimonidine 0.5% than 0.2% [1,2]. It can also cause allergic conjunctivitis and ocular pruritus [3].

Does brimonidine affect the heart?

If itching, redness, swelling, or other signs of eye or eyelid irritation occur, stop using this medicine and check with your doctor. These signs may mean that you are allergic to this medicine. This medicine may cause heart failure in some patients.

What drugs interact with brimonidine?

Some products that may interact with this drug include: beta-blockers (such as atenolol, metoprolol, timolol eye drops), digoxin, high blood pressure medications (such as clonidine, terazosin), tricyclic antidepressants (such as amitriptyline).