Is clopidogrel an anticoagulant?

Clopidogrel is an antiplatelet medicine. It prevents platelets (a type of blood cell) from sticking together and forming a dangerous blood clot. Taking clopidogrel helps prevent blood clots if you have an increased risk of having them.

What is clopidogrel mechanism of action?

The active metabolite of clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP- mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. This action is irreversible.

What is the indication of clopidogrel?

FDA-approved indications for clopidogrel include: Use during a percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) and stable ischemic heart disease. [4][5][6] Primary prevention of thromboembolism atrial fibrillation.

What is clopidogrel used for and side effects?

Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease).

What is another name for clopidogrel?

Plavix (clopidogrel bisulfate) is a thienopyridine class of drug that inhibits platelet aggregation and thus inhibits aspects of blood clotting used to treat patients with acute coronary syndrome, myocardial infarction (MI), peripheral vascular disease and some stroke (ischemic type) patients.

What are the contraindications of clopidogrel?

Clopidogrel is contraindicated in patients with a known hypersensitivity to clopidogrel or any component of the product. Clopidogrel increases the risk of bleeding and is contraindicated in patients with active pathological bleeding including GI bleeding and intracranial bleeding.

What are the long term effects of clopidogrel?

Clopidogrel may make you bruise and bleed more easily, have nosebleeds, and it will take longer than usual for bleeding to stop. You should tell your doctor about any serious bleeding, such as: unexplained, prolonged, or excessive bleeding. blood in your urine or stool.

What is the difference between aspirin and clopidogrel?

Aspirin and Plavix (clopidogrel bisulfate) are drugs used to prevent blood clots. Aspirin and Plavix belong to different drug classes. Plavix is an anticoagulant and aspirin is a nonsteroidal anti-inflammatory drug (NSAID). Aspirin also is used to reduce fever, and to treat pain and inflammation in the body.

What is the difference between aspirin and clopidogrel?

Aspirin and Plavix (clopidogrel bisulfate) are drugs used to prevent blood clots. Aspirin and Plavix belong to different drug classes. Plavix is an anticoagulant and aspirin is a nonsteroidal anti-inflammatory drug (NSAID). Aspirin also is used to reduce fever, and to treat pain and inflammation in the body.

What is the mechanism of action of clopidogrel quizlet?

Mechanism of action? Clopidogrel is an antiplatelet agent that prevents platelet aggregation by direct inhibition of ADP binding to receptor sites, inhibiting subsequent activation of the gly- coprotein IIb/IIIa complex.

Is clopidogrel a beta blocker?

Plavix is not a beta-blocker. Beta-blocker drugs such as metoprolol act on beta-adrenergic receptors in the body. On the other hand, Plavix acts on the receptors on the platelet, such as P2Y12 receptors. Plavix blocks these receptors and prevents platelet aggregation from forming clots.

Is clopidogrel a COX inhibitor?

Aspirin (ASA) and clopidogrel have been identified as standard of care in the prevention of major cardiovascular events. Aspirin irreversibly inhibits the cyclooxygenase-1 (COX-1) enzyme, whereas non-steroidal anti-inflammatory drugs (NSAIDs) reversibly inhibit the COX-1 enzyme.

In which organ is clopidogrel activated for its drug effects?

Clopidogrel is a prodrug that is absorbed in the intestine [3,4] and activated in the liver [5].

Is clopidogrel an ACE inhibitor?

Aims. Clopidogrel and angiotensin converting enzyme (ACE) inhibitors are commonly co-prescribed drugs. Clopidogrel inhibits carboxylesterase 1 (CES1), the enzyme responsible for converting prodrug ACE inhibitors (such as ramipril and perindopril) to their active metabolites.

Is clopidogrel a calcium channel blocker?

Clopidogrel is an inactive prodrug; it is converted to its active metabolite through the cytochrome P450 (CYP3A4) pathway, which also metabolizes calcium channel blockers (CCBs).

Is clopidogrel a statin?

Statins are lipid-lowering agents, whereas clopidogrel is an antiplatelet agent. Clinicians commonly prescribe both medications for patients to prevent atherosclerotic cardiovascular disease (ASCVD).

What are examples of ACE inhibitors?

Angiotensin-converting enzyme inhibitor (ACE inhibitors) drugs include Benazepril (Lotensin), Captopril (Capoten), Enalapril/Enalaprilat (Vasotec oral and injectable), Fosinopril (Monopril), Lisinopril (Zestril and Prinivil), Moexipril (Univasc), Perindopril (Aceon), Quinapril (Accupril), Ramipril (Altace), and …

What drug category is ACE inhibitors?

Examples of ACE inhibitors include: Benazepril (Lotensin) Captopril. Enalapril (Vasotec)

What are ACE inhibitors and beta blockers?

They are both used for conditions like high blood pressure and heart failure. ACE inhibitors mainly lower blood pressure by relaxing blood vessels in the body. Beta blockers mainly lower the heart rate, but they can also relax blood vessels.

Is aspirin an ACE inhibitor?

Aspirin blocks prostaglandin production, whereas ACE inhibitors tend to increase it. Animal experiments have shown that aspirin can block ACE inhibitor–induced vascular relaxation. Studies have also suggested that the combination of aspirin and ACE inhibitors may have an adverse effect on renal function.