Classification of gentamicin
What classification is Garamycin?
It belongs to a class of drugs known as aminoglycoside antibiotics. This antibiotic only treats bacterial infections.
What is the mechanism of action of gentamicin?
Gentamicin is bactericidal and is a broad spectrum antibiotic (except against streptococci and anaerobic bacteria). Its mechanism of action involves inhibition of bacterial protein synthesis by binding to 30S ribosomes.
What is the indication of gentamicin?
Indications : gentamicin is indicated in bacteraemia, urinary tract infections, chest infections, severe neonatal infections and other serious systemic infections due to susceptible organisms, in adults and children including neonates.
What is the common name for gentamicin?
Gentamicin
| Clinical data | |
|---|---|
| Trade names | Cidomycin, Genticyn, Garamycin, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682275 |
| License data | US DailyMed: Gentamicin |
What is the contraindication of gentamicin?
According to the manufacturer’s label, absolute contraindication for gentamicin use is a history of hypersensitivity reaction to it or other aminoglycosides, although this is rare.
What are the properties of gentamicin?
Basic Chemistry
| Chemical Structure | |
|---|---|
| Structure | |
| Properties | |
| Physical Properties | Gentamicin sulfate is a white-buff powder that melts with decomposition between 220oC and 240oC. |
| Molecular Weight | 447.529 |
Is gentamicin a penicillin?
Tetracyclines (e.g. doxycycline), quinolones (e.g. ciprofloxacin), macrolides (e.g. clarithromycin), aminoglycosides (e.g. gentamicin) and glycopeptides (e.g. vancomycin) are all unrelated to penicillins and are safe to use in the penicillin allergic patient.
Is gentamicin an antifungal?
Major fractions of the gentamicin complex (C1, C1a, C2, C2a) possess weak antifungal activity and one of the minor components (A, A1–A4, B, B1, X), gentamicin B1 was found to be a strong antifungal agent.
What is the antidote for gentamicin?
Pyridoxal 5′-phosphate as an antidote for cyanide, spermine, gentamicin, and dopamine toxicity: an in vivo rat study. Toxicol Appl Pharmacol.
What is the MOA of aminoglycosides?
The mechanism of action of aminoglycosides depends on the inhibition of polypeptide synthesis. In fact, some of them such as Streptomycin, Sisomicin and Gentamicin are believed to cause codon misreading, by increasing the incorporation of certain aminoacids into polypeptide in the ribosome-polyribonucleotide system.
What is the mechanism of action of ampicillin?
The mechanisms of action of ampicillin are interference with cell wall synthesis by attachment to penicillin-binding proteins (PBPs), inhibition of cell wall peptidoglycan synthesis and inactivation of inhibitors to autolytic enzymes.
What are two serious side effects of gentamicin?
If you experience any of the following symptoms, call your doctor immediately: hearing loss, roaring or ringing in the ears, or dizziness. Gentamicin may cause nerve problems. Tell your doctor if you have or have ever had burning or tingling in the hands, arms, feet, or legs; muscle twitching or weakness; or seizures.
What is the mechanism of action of tobramycin?
Tobramycin works by binding to a site on the bacterial 30S and 50S ribosome, preventing formation of the 70S complex. As a result, mRNA cannot be translated into protein, and cell death ensues. Tobramycin also binds to RNA-aptamers, artificially created molecules to bind to certain targets.
What is another name for ampicillin?
Ampicillin is available under the following different brand names: Ampi, Omnipen, Penglobe, and Principen.
What drug classification is ampicillin?
Ampicillin is in a class of medications called penicillins. It works by killing bacteria. Antibiotics such as ampicillin will not work for colds, flu, or other viral infections.
What is the generic name of ampicillin?
PRINCIPEN Capsules (Ampicillin Capsules) and PRINCIPEN for Oral Suspension (Ampicillin for Oral Suspension) are indicated in the treatment of infections caused by susceptible strains of the designated organism listed below; Infections of the Genitourinary Tract Including Gonorrhea: E. coli, P.
What’s another name for doxycycline?
Brand names: Vibramycin-D, Efracea, Periostat.
Is gentamicin a penicillin?
Tetracyclines (e.g. doxycycline), quinolones (e.g. ciprofloxacin), macrolides (e.g. clarithromycin), aminoglycosides (e.g. gentamicin) and glycopeptides (e.g. vancomycin) are all unrelated to penicillins and are safe to use in the penicillin allergic patient.