Classification of non depolarising muscle relaxants
What are the non-depolarizing muscle relaxants?
Non-depolarizing blocking agents
| Agent | Time to onset (seconds) | Duration (minutes) |
|---|---|---|
| Cisatracurium (Nimbex) | 90 | 60–80 |
| Vecuronium (Norcuron) | 60 | 30–40 |
| Rocuronium (Zemuron) | 75 | 45–70 |
| Pancuronium (Pavulon) | 90 | 180 or more |
What is the difference between Depolarising and Nondepolarizing muscle relaxants?
Thus, depolarizing muscle relaxants act as ACh receptor agonists, whereas nondepolarizing muscle relaxants function as competitive antagonists. This basic difference in mechanism of action explains their varying effects in certain disease states.
What is a Depolarising muscle relaxant?
There are 2 types of neuromuscular blocking agents that work at the neuromuscular junction: depolarizing and non-depolarizing. Depolarizing muscle relaxants act as acetylcholine (ACh) receptor agonists by binding to the ACh receptors of the motor endplate and generating an action potential.
What are Nondepolarizing agents?
Nondepolarizing neuromuscular blockers are competitive acetylcholine (ACh) antagonists that bind directly to nicotinic receptors on the postsynaptic membrane, thus blocking the binding of ACh so the motor endplate cannot depolarize. [4] This leads to muscle paralysis.
What is another name for succinylcholine?
Succinylcholine is available under the following different brand names: Anectine and suxamethonium.
How are non-depolarizing muscle relaxants excreted?
Approximately 40% to 50% of a long-acting nondepolarizing muscle relaxant, pancuronium, is excreted in urine. A portion of this excretion occurs after biotransformation to the less active metabolite 3-hydroxypancuronium.
What type of drug is rocuronium?
Rocuronium is a non-depolarizing neuromuscular blocker widely used to produce muscle relaxation to help facilitate surgery and ventilation of the lungs in elective and emergent situations.
What class of drug is atracurium?
Atracurium is a non-depolarizing neuromuscular blocking drug of the benzylisoquinolinium class.
What is the mechanism of action of rocuronium?
Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium.
What type of drug is rocuronium?
Rocuronium is a non-depolarizing neuromuscular blocker widely used to produce muscle relaxation to help facilitate surgery and ventilation of the lungs in elective and emergent situations.
What type of drug is atracurium?
Atracurium is a non-depolarizing neuromuscular blocking drug of the benzylisoquinolinium class. It competes with acetylcholine for binding sites. This activity outlines the indications, mechanism of action, safe administration, adverse effects, contraindications, toxicology, and monitoring of atracurium.
What is the mechanism of action of rocuronium?
Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium.
What is rocuronium used for?
Rocuronium injection is used with general anesthesia medicines for rapid sequence intubation and routine tracheal intubation. This medicine is also used to help relax the muscles during surgery or mechanical ventilation. This medicine is to be given only by your doctor or other trained health professional.
What is the difference between atracurium and rocuronium?
Conclusion: Rocuronium has minimal side effects, provides conditions more suitable for rapid tracheal intubation, and is associated with a shorter clinical duration than atracurium. Once begun, the spontaneous recovery profile of rocuronium is slightly slower than that of atracurium.
What is the difference between atracurium and Cisatracurium?
We can conclude that at the same dose (2×ED95 dose) atracurium is more effective neuromuscular blocking agent than cisatracurium, while higher doses of cisatracurium provide more effective, more rapid neuromuscular blocking with longer duration of action, stable hemodynamic status, and no associated signs of histamine …
What is the difference between atracurium and vecuronium?
Both agents produce a lower degree of histamine release than other agents, although atracurium appears to produce a higher incidence of histamine-like reactions than vecuronium. Vecuronium appears to be the agent of choice in patients with a history of asthma or allergy.
What is the difference between rocuronium and Cisatracurium?
Cisatracurium is four to five times more potent than rocuronium. Rocuronium had a faster onset of action, a shorter clinical duration, and a faster spontaneous recovery rate compared with equipotent doses of cisatracurium.
When do you use succinylcholine vs rocuronium?
What’s your paralytic of choice for this patient? Succinylcholine has been traditionally used as a first-line paralytic due to its quick onset of action and short half-life. Succinylcholine’s duration of action is 10—15 minutes, whereas the half-life of rocuronium is anywhere from 30—90 minutes, depending on the dose.