How do you classify splenomegaly?

Splenomegaly can be classified based on its pathophysiologic mechanism: Congestive, by pooled blood (e.g., portal hypertension) Infiltrative, by invasion by cells foreign to the splenic environment (e.g., metastases, myeloid neoplasms, lipid storage diseases)

What are 3 diseases that affect the spleen?

Disorders of the spleen include splenomegaly, hypersplenism and splenic rupture.

How many types of spleen are there?

two types
Surrounded by a connective tissue capsule, which extends inward to divide the organ into lobules, the spleen consists of two types of tissue called white pulp and red pulp.

What is the main cause of splenomegaly?

Many conditions — including infections, liver disease and some cancers — can cause an enlarged spleen. An enlarged spleen is also known as splenomegaly (spleh-no-MEG-uh-lee).

What are the 3 main functions of the spleen?

The spleen has some important functions: it fights invading germs in the blood (the spleen contains infection-fighting white blood cells) it controls the level of blood cells (white blood cells, red blood cells and platelets) it filters the blood and removes any old or damaged red blood cells.

What is normal spleen size?

Normally, the spleen does not extend inferior to the left costal margin; hence a normal spleen is seldom palpable through the anterolateral abdominal wall. It varies in size and shape but it is usually 12 cm long, 5 cm thickness, and 7 cm wide.

What is the best treatment for splenomegaly?

Your doctor might recommend surgery to remove your spleen (splenectomy) for diagnostic purposes when there’s no identifiable cause for the enlargement. More often, the spleen is removed as treatment. After surgery to remove it, the spleen is examined under a microscope to check for possible lymphoma of the spleen.

Which antibiotic is best for splenomegaly?

Possible choices of empiric antimicrobial agents include cefotaxime (adult dose of 2 g IV q8h; pediatric dose of 25-50 mg/kg IV q6h) or ceftriaxone (adult dose of 2 g q12-24h; pediatric dose of 50 mg/kg IV q12h).

What infections cause enlarged spleen?

Infections, liver problems, blood cancers, and metabolic disorders can all cause your spleen to become enlarged, a condition called splenomegaly.

What are warning signs of the spleen?

Pain in the upper left abdomen. Tenderness when you touch the upper left abdomen. Left shoulder pain. Confusion, lightheadedness or dizziness.

What viral disease can cause damage to the spleen?

As one of the functions of the spleen is to help in immune system, large spleen can be as a result of infection. Infections can either be viral (e.g.: Infectious mononucleosis which can cause enlarged and fragile spleen) or hepatitis, malaria, and brucellosis.

What do spleen problems feel like?

Spleen pain is usually felt as a pain behind your left ribs. It may be tender when you touch the area. This can be a sign of a damaged, ruptured or enlarged spleen.

What autoimmune disease causes enlarged spleen?

Felty syndrome is a rare form of rheumatoid arthritis, a disorder characterized by painful, stiff, and swollen joints. Major symptoms and physical findings of Felty syndrome include an unusually large spleen (splenomegaly) and abnormally low levels of certain white blood cells (neutophils [neutropenia]).

What is the best treatment for splenomegaly?

Your doctor might recommend surgery to remove your spleen (splenectomy) for diagnostic purposes when there’s no identifiable cause for the enlargement. More often, the spleen is removed as treatment. After surgery to remove it, the spleen is examined under a microscope to check for possible lymphoma of the spleen.

Which antibiotic is best for splenomegaly?

Possible choices of empiric antimicrobial agents include cefotaxime (adult dose of 2 g IV q8h; pediatric dose of 25-50 mg/kg IV q6h) or ceftriaxone (adult dose of 2 g q12-24h; pediatric dose of 50 mg/kg IV q12h).

What cancers cause enlarged spleen?

The most common causes of spleen cancer are lymphomas and leukemias.

What drugs cause splenomegaly?

Chemotherapeutic drugs (eg, oxaliplatin, fluorouracil, bevacizumab, etc) are often implicated in drug-induced splenomegaly. RhoGAM is also known to cause splenomegaly in some patients.