What are the three types of suppository bases?

There are two types of suppository base – lipophilic base (e.g. cocoa butter, hard fats) which is melted at body temperature, and hydrophilic base (e.g. gelatin, polyethylene glycol) which is dissolved in rectal fluid to release the drug [106,114].

What is suppositories and type of suppositories?

Listen to pronunciation. (suh-PAH-zih-TOR-ee) A form of medicine contained in a small piece of solid material, such as cocoa butter or glycerin, that melts at body temperature. A suppository is inserted into the rectum, vagina, or urethra and the medicine is absorbed into the bloodstream.

What are suppositories and its types in pharmaceutics?

Suppositories have a base made from substances like gelatin or cocoa butter that surrounds the drug. As the warmth of your body melts the outside, the drug slowly releases. Different types of suppositories go into the rectum, vagina, or the duct that empties your bladder, called the urethra.

What are the properties of suppositories?

IDEAL PROPERTIES OF SUPPOSITORY BASES

It should melt at body temperature or dissolve or disperse in body fluids. It should release any medicament easily. It should keep its shape when being handled. It should be non-toxic and non-irritant to the mucous membrane.

What are the names of suppositories?

Glycerin rectal is available under the following different brand names: Fleet Glycerin Suppositories, Fleet Liquid Glycerin Suppositories, Pedia-Lax Glycerin Suppositories, and Pedia-Lax Liquid Glycerin Suppositories.

What are the 3 methods used in the preparation of suppositories?

Three methods are used to prepare a suppository: hand molding, fusion, and compression.

What is suppository advantages and disadvantages?

Avoid first pass metabolism. Introduce drugs into the body. Does not cause nausea and vomiting due to gastric irritation in case of oral therapy. Used before surgery since oral therapy is restricted.

What is the formulation of suppositories?

Suppositories are prepared using bases as vehicles. The bases are of two types: oleagineous/fatty bases (theobroma oil or cocoa butter and hydrogenated vegetable oils) and water miscible or soluble (glycerinated gelatin and polyethylene glycol polymers also known as macrogols).

What is preparation of suppositories?

Fusion Molding involves first melting the suppository base, and then dispersing or dissolving the drug in the melted base. The mixture is removed from the heat and poured into a suppository mold. When the mixture has congealed, the suppositories are removed from the mold.

What are the two types of suppository base?

Traditionally cylindrical in shape, suppositories can be classified into two base types: lipophilic and hydrophilic. Lipophilic suppositories are primarily fat- or wax-based and melt at human body temperature. Hydrophilic suppositories are polymer or glycerin based and require fluids to dissolve.

Which drug is used as suppository base?

PEGS, water soluble polymers of ethylene glycol, are used as suppository bases. These are tolerant to cations, to insoluble drugs and are relatively unaffected by the variations in pH. They are chemically inert and do not cause physiolgical side effects (1, 2).

What is suppositories PDF?

Suppositories: “Suppositories are solid bodies of various weights and shapes, adapted for introduc- tion into the rectal, vaginal, or urethral orifice of the human body.They usually melt, soften, or. dissolve at body temperature. A suppository may act as a protectant or palliative to the local tis-

What are suppository bases?

Suppository base excipients are used in the manufacture of suppositories (for rectal administration) and pessaries (for vaginal administration). They can be hydrophobic or hydrophilic. Suppositories should melt at just below body temperature (37 C), which allows for erosion of the dosage form and release of the API.

Why is glycerol used in suppositories?

Glycerol is commonly classified as an osmotic laxative but may act additionally or alternatively by promoting peristalsis and evacuation of the lower bowel by virtue of a mild irritant effect. Glycerol suppositories possess also lubricating and faecal softening actions.

Which suppository is best for constipation?

Glycerol suppositories are used to treat constipation. They can be bought without a prescription at pharmacies and other retail outlets. Glycerol is a mild irritant. It works by encouraging muscles around your back passage to contract.

What are the two uses of glycerol?

Glycerol is used as a solvent for flavors and food colors. It is also used as a humectant, plasticizer, emollient, sweetener, and filler in low-fat food products such as cookies.

How many suppositories can you use?

How many do I use? Adults should use one 4g suppository. Initially it is best to try to use one suppository at a time convenient to you. First thing in the morning is often most successful as this is a time when the urge to empty your bowel may be strongest.

What are suppositories used for?

Rectal suppositories are forms of medication that are inserted into the rectum. They come in different shapes and sizes but are usually narrowed at one end. Rectal suppositories can deliver many types of medication. For instance, they may contain glycerin to treat constipation or acetaminophen to treat a fever.

What is the side effect of suppository?

Risks and side effects

Some people may experience irritation around the area where they inserted the suppository. If this is severe or persists, they should see a doctor. Occasionally, the body may not absorb the medication delivered by a suppository as well as it does oral medications.

How do you insert a suppository?

Lift upper buttock to expose the rectal area. Insert the suppository, pointed end first, with your finger until it passes the muscular sphincter of the rectum, about 1/2 to 1 inch in infants and 1 inch in adults. (If not inserted past this sphincter, the suppository may pop out.)

Which side of the suppository goes in first?

Historically suppositories were inserted pointed end first until the publication of a small study by Abd-El-Maeboud et al (1991) who recommended that suppositories were inserted blunt end first.