Classification of thiamine
What is the drug thiamine used for?
Man-made thiamine can be used to treat or prevent vitamin B1 deficiency (this is when you do not have enough of this vitamin in your body). It is sometimes also used to treat to children with rare conditions like maple syrup urine disease and congenital lactic acidosis.
What is the mechanism of action of thiamine?
Mechanism of Action
Thiamin is a water-soluble vitamin and is absorbed into the blood from the gastrointestinal tract. It then circulates in the blood and ultimately gets excreted in the urine. Small amounts of thiamin are stored in the liver, heart, kidney, and brain, but only for a short duration.
What is the common name for thiamine?
Thiamin (thiamine), or vitamin B1, is a water-soluble vitamin found naturally in some foods, added to foods, and sold as a supplement. Thiamin plays a vital role in the growth and function of various cells. [1] Only small amounts are stored in the liver, so a daily intake of thiamin-rich foods is needed.
What is the main cause of thiamine deficiency?
A diet consisting mainly of white flour, white sugar, and other highly processed carbohydrates can cause thiamin deficiency. At first, people have vague symptoms such as fatigue and irritability, but a severe deficiency (beriberi) can affect the nerves, muscles, heart, and brain.
Who needs thiamine?
People take thiamine for conditions related to low levels of thiamine, including beriberi and inflammation of the nerves (neuritis). It’s also used for digestive problems, diabetic nerve pain, heart disease, and other conditions, but there is no good scientific evidence to support these other uses.
Is thiamine a protein?
Thiamine, also known as thiamin and vitamin B1, is a vitamin, an essential micronutrient, which cannot be made in the body.
Where is thiamine found?
Foods high in thiamin include pork, fish, seeds, nuts, beans, green peas, tofu, brown rice, squash, asparagus, and seafood. The current daily value (DV) for vitamin B1 is 1.2mg. Below is a list high thiamin foods ranked by a common serving size.
Where is thiamine produced in the body?
The human body does not produce endogenous thiamine; therefore, it must be ingested. Various dietary sources of thiamine include meat (e.g., pork, poultry), whole grain cereals (e.g., brown rice and bran), nuts, dried beans, peas, and soybeans. Breads and cereals are commonly fortified with thiamine.
Who should not take thiamine?
You should not use thiamine if you have ever had an allergic reaction to it. Ask a doctor or pharmacist if it is safe for you to take this medicine if: you have any other medical conditions; you take other medications or herbal products; or.
When should you take thiamine?
Thiamine tablets are usually taken once a day. Doses of 25-100 mg are sufficient to prevent mild deficiency. You can take the tablets at whatever time of day you find easiest to remember, either before or after meals.
Why do we give thiamine to alcoholics?
Thiamine deficiency is the established cause of an alcohol–linked neurological disorder known as Wernicke–Korsakoff syndrome (WKS), but it also contributes significantly to other forms of alcohol–induced brain injury, such as various degrees of cognitive impairment, including the most severe, alcohol–induced persisting …
Where is thiamine found?
Foods high in thiamin include pork, fish, seeds, nuts, beans, green peas, tofu, brown rice, squash, asparagus, and seafood. The current daily value (DV) for vitamin B1 is 1.2mg. Below is a list high thiamin foods ranked by a common serving size.
How much thiamine is safe?
A daily dose of 50 to 100 mg is often taken as a supplement. Thiamine appears safe in these doses. But you should talk to your doctor before taking a large amount.
Does thiamine help you sleep?
Thiamin supplementation also tended to reduce daytime sleep time, improve sleep patterns, and increase activity.
Is thiamine a protein?
Thiamine, also known as thiamin and vitamin B1, is a vitamin, an essential micronutrient, which cannot be made in the body.
Who discovered thiamine?
In 1926, Barend Jansen and Willem Donath isolated and crystallized a substance that cured polyneuritis in pigeons. Robert Williams synthesized thiamin in 1936.
Is thiamin an antioxidant?
Thiamin is an antioxidant, necessary for the production of energy and right functioning of neurons. Thiamine deficiency (TD) models the impairment of oxidative metabolism and reduction in thiamin-dependent processes leads to neurodegenerative disorders.
Is thiamine an enzyme?
Thiamine diphosphate is a coenzyme of many enzymes, most of which occur in prokaryotes. Pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes as well as transketolase are the examples of thiamine-dependent enzymes present in eukaryotes, including human.
Is thiamine a micronutrient?
Micronutrients are one of the major groups of nutrients your body needs. They include vitamins and minerals.
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Water-Soluble Vitamins.
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Water-Soluble Vitamins.
| Nutrient | Sources | RDA or AI (adults > 19 years) |
|---|---|---|
| Vitamin B1 (thiamine) | Whole grains, meat, fish | 1.1–1.2 mg |
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27 sept 2018