What are the different types of cytopenia?

There are several types of cytopenia depending on what type of blood cells are depleted:
  • Anaemia – reduced red blood cells.
  • Neutropenia – reduced white blood cells.
  • Thrombocytopenia – reduced numbers of platelets.
  • Pancytopenia – deficiency in all types of blood parts.

What causes cytopenia?

The possible causes of cytopenia are complex and varied. Among these causes are peripheral destruction, infections, and side effects of medication. Two types of cytopenia that are related to the underlying cause of the low blood cell count are autoimmune cytopenia and refractory cytopenia.

Is cytopenia the same as anemia?

Cytopenia, defined by a reduced number of blood cells manifesting as either anemia, neutropenia, and/or thrombocytopenia (1), may be associated with multiple conditions, including cancer, bone marrow suppression from chemotherapy or radiotherapy, as well as pregnancy, nutrient deficiencies, liver disease, hypersplenism …

What’s the difference between pancytopenia and thrombocytopenia?

Pancytopenia occurs when you have a combination of three different blood disorders: Anemia is when you have too few red blood cells. Leukopenia is when you have too few white blood cells. Thrombocytopenia is when you have too few platelets.

Can Vitamin B12 deficiency cause pancytopenia?

Deficiency of vitamin B12 is a well known cause of megaloblastic anemia and pancytopenia. Splenomegaly and leukoerythroblastosis are much less well known manifestations of B12 deficiency.

What drugs can cause pancytopenia?

chemotherapy treatments, including methotrexate, carbamazepine, and chloramphenicol. certain medications, such as trimethoprim-sulfamethoxazole (Bactrim) toxicity from drugs or chemotherapy agents. inherited conditions, such as Fanconi’s anemia.

What are 5 causes of pancytopenia?

The most common causes leading to Pancytopenia on Bone Marrow examination are Hypoplastic (AA) bone marrow (29.05%), Megaloblastic anemia (MA) (23.64%), Hematological malignancies i.e. Acute Myeloid Leukemia (AML) (21.62%), and Erythroid hyperplasia (EH) (19.6%).

What infection can cause pancytopenia?

Pancytopenia causes and risk factors
  • Epstein-Barr virus, which causes mononucleosis.
  • cytomegalovirus.
  • HIV.
  • hepatitis.
  • malaria.
  • sepsis (a blood infection)

What is main cause of pancytopenia?

Pancytopenia may be caused by certain autoimmune, bone marrow, or genetic disorders. It may also be caused by infection, poor nutrition, pregnancy, cancer treatment (such as chemotherapy or radiation therapy), or exposure to certain toxins, chemicals, or medicines.

What infection causes pancytopenia?

Sepsis causes pancytopenias through several mechanisms (marrow suppression, hypersplenism, and consumptive coagulopathy), which usually act in combination. The virus causes pancytopenia through several mechanisms with modulation of the hematopoietic stem cells.

What is pancytopenia and what causes it?

Pancytopenia occurs when there is a problem with the blood-forming stem cells in the bone marrow. Signs and symptoms include fatigue, weakness, dizziness, trouble breathing, fast heartbeat, fever, pale skin, purple or red spots on the skin, rash, easy bruising, and abnormal bleeding.

Is B12 deficiency linked to leukemia?

Vitamin B12 deficiency can cause profound alterations in the bone marrow. These alterations can mimic the more serious diagnosis of acute leukemia.

What are autoimmune cytopenias?

Autoimmune cytopenias are a group of heterogeneous but closely related conditions defined by immune-mediated destruction of hematologic cell lineages, including white blood cells (neutrophils), red blood cells, and platelets. This destruction can be primary or secondary to other illnesses.

Does liver disease cause pancytopenia?

Pancytoopenia in chronic liver disease can be due to hyper-splenism, megaloblastic anemia and primary marrow suppression. Hypersplenism is most frequent cause of pancytopenia in chronic liver disease.